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4D syndrome

Last revised by Dr Jeremy Jones on 29 Aug 2021

4D syndrome is a term used to describe a manifestation of syndromic glucagonoma, a type of pancreatic endocrine tumor.

  • D: dermatitis 2
    • necrolytic migratory erythema - a widespread rash, tending to involve perioral and perigenital regions
    • oral rashes (angular stomatitis, cheilitis)
    • tend to resolve upon removal of the tumor
  • D: mild diabetes mellitus
  • D: deep vein thrombosis
  • D: depression - may be related to severe chronic dermatosis 2

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