Bartter syndrome is a rare inherited renal disorder.
Bartter syndrome is characterized by hyperplasia of the juxtaglomerular cells along with:
- metabolic alkalosis
- elevated plasma renin
- elevate aldosterone
- antenatal polyhydramnios
There are two subtypes of Bartter syndrome:
- classic: presents in early childhood with polyuria, polydipsia with a predisposition to dehydration
- neonatal: presents earlier
History and etymology
First described in 1962 by American physician Frederic Crosby Bartter (1914-1983).
- 1. Vieira H, Mendes L, Mendes P et-al. Classic Bartter syndrome: a rare cause of failure to thrive in a child. BMJ Case Rep. 2012;2012 (jun28 1): . doi:10.1136/bcr.02.2012.5888 - Free text at pubmed - Pubmed citation
- 2. Cunha TDS, Heilberg IP. Bartter syndrome: causes, diagnosis, and treatment. (2018) International journal of nephrology and renovascular disease. 11: 291-301. doi:10.2147/IJNRD.S155397 - Pubmed