Brownell-Oppenheimer variant of sporadic Creutzfeldt-Jakob disease

The Brownell-Oppenheimer phenotypic variant of sporadic Creutzfeldt-Jakob disease (CJD) is a distinct clinical entity with predominant gait ataxia, linked to molecular subtype VV2 1,2. The EEG findings in patients with Oppenheimer-Brownell phenotype usually reveal the absence of periodic sharp-wave complexes (PSWCs) 1,2. The protein 14-3-3 is usually elevated in CSF analysis in patients with VV2 variant of sCJD 2. MRI shows cerebellar atrophy and selective signal abnormalities in the cerebellar cortex 1.

Neurodegenerative diseases

Neurodegenerative diseases are legion and their classification just as protean. A useful approach is to divide them according to underlying pathological process, although even using this schema, there is much overlap and thus resulting confusion.

Article information

rID: 74054
Tag: stub
Synonyms or Alternate Spellings:
  • CJD (Oppenheimer-Brownell variant)

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