Chorea is a type of dyskinesia characterized by sudden, rapid, involuntary, and purposeless movements that happen during a person’s normal voluntary movement.
It is a clinical symptom related to different etiologies, such as infectious, inflammatory, vascular, hereditary (e.g. Huntington's disease), drug-induced, degenerative, and neoplastic causes 1,2.
Despite the fact that the pathophysiology of chorea is not fully understood, it is thought that it is a consequence of dysfunctional neuronal networks interconnecting the basal ganglia and frontal cortical motor areas, where a deficit in inhibitory signals from the basal ganglia lead to extra and unwanted movements 1.
- 1. Cardoso F, Seppi K, Mair KJ et-al. Seminar on choreas. Lancet Neurol. 2006;5 (7): 589-602. doi:10.1016/S1474-4422(06)70494-X - Pubmed citation
- 2. Wild EJ, Tabrizi SJ. The differential diagnosis of chorea. Pract Neurol. 2007;7 (6): 360-73. doi:10.1136/pn.2007.134585 - Pubmed citation
- 3. Cardoso F. Chorea: non-genetic causes. Curr. Opin. Neurol. 2004;17 (4): 433-6. Pubmed citation