Granulomatosis with polyangiitis (renal manifestations)
The renal manifestations of granulomatosis with polyangiitis (GPA) (previously known as Wegener granulomatosis) are occult on imaging, especially when compared to the pulmonary changes. Approximately half of GPA patients have kidney disease at presentation. Granulomatosis with polyangiitis is a multisystem systemic necrotizing non-caseating granulomatous vasculitis affecting small to medium-sized arteries, capillaries and veins.
Reduced renal function, proteinuria and hematuria.
GPA affects the kidneys with the development of necrotizing glomerulonephritis in ~60% (range 39-80%) of patients.
- 1. Oxford Textbook of Vasculitis (Oxford Textbooks in Rheumatology). Oxford University Press. ISBN:0199659869. Read it at Google Books - Find it at Amazon
- 2. Oxford desk reference. Oxford University Press. ISBN:0199229562. Read it at Google Books - Find it at Amazon
- 3. Ferri's Clinical Advisor 2016: 5 Books in 1, 1e (Ferri's Medical Solutions). Elsevier. ISBN:0323280471. Read it at Google Books - Find it at Amazon