Macrocephaly

Macrocephaly is a clinical and radiological term that refers to a generalized increase in the size of the cranial vault.

This slightly differs from the term megalencephaly which means an increase in the size of the brain parenchyma. 

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In some individuals a large head is normal or something that is familial.

However in others it is related to a syndrome, and other features may be present, see long list of causes below. 

In an infant it can result from a wide range of causes:

Some define the condition on skull radiography when the head circumference is more than two standard deviations above the mean or exceeds the 97th percentile by at least 0.5 cm 4.

Malformations of the central nervous system

Article information

rID: 9170
Synonyms or Alternate Spellings:
  • Large head in infancy

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Cases and figures

  • Case 1: mucopolysaccharidosis
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  • Case 2: achondroplasia
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  • Mucopolysaccharid...
    Case 3: mucopolysaccharidosis
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