Neurolymphomatosis is a rare condition characterized by the direct invasion of the cranial and peripheral nerves and roots by lymphoma, in the great majority B-cell non-Hodgkin lymphoma.

It should be differentiated from non-tumor conditions associated with lymphoma that also affect the peripheral nervous system, such as irradiation, chemotherapy, or paraneoplastic effects.

Neurolymphomatosis seems to be the least common neurologic manifestation of lymphoma 3.

The symptoms may vary broadly, including painful plexopathy, cranial nerve palsies with or without pain, painful or painless mononeuropathy, and foot drop 1,3.

Brain or spinal MRI can spot a nerve or root enlargement and/or enhancement 1,3, sometimes with a nodular thickening.


Article information

rID: 40985
Synonyms or Alternate Spellings:
  • Nerve infiltration by lymphoma
  • Lymphoma nerve infiltration

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