Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS)
Recent increase in unsteadiness with associated sensory peripheral neuropathy.
MRI Brain and Spine
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BRAIN: Cerebellar atrophy is marked, especially in the region of the lower vermis. Moderate generalized cerebral atrophy. Brainstem is normal. Moderate midbrain atrophy. Diffuse white matter hyperintensity consistent with small vessel type ischemia.
CERVICAL SPINE: Central canal is capacious. Slight loss of the
normal cervical enlargement, spinal cord caliber appears below average.
1 case question available
This case demonstrates a patient with cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS). It depicts common MRI findings of focal cerebellar atrophy, particularly in the vermis, as well as spinal cord atrophy, most notably in the cervical region. This patient was diagnosed with CANVAS 10 years prior to this presentation at a tertiary center and was found to have a positive family history of neurodegenerative disorders; this patient has two family members who suffer from multiple sclerosis.