Neuromyelitis optica (NMO)

Case contributed by Assoc Prof Frank Gaillard


Previous well with rapidly evolving lower upper motor neuron weakness and signs. Bladder dysfunction. Brain MRI normal.

Patient Data

Age: 40 years
Gender: Female

Involving the cervicothoracic cord is a longitudinally extensive spinal cord lesion (LESCL) of an abnormal T2 signal with cord swelling. The central cord is involved. No hemorrhage. 


Case Discussion

The patient went on to have extensive diagnostic work-up. 

  • Neuromyelitis Optica antibodies: POSITIVE
  • Rheumatoid Antibodies
    • Rheumatoid Factor <20 IU/mL (normal range: <20)
  • Antinuclear Antibodies
    • Antinuclear antibodies: POSITIVE
    • Speckled Titer: 40
    • Speck/Nuclr Titer: 640
  • Extractable Nuclear Antigens
    • Ext. Nuclear Ags Positive
    • Anti - Sm: Negative
    • Anti - RNP: Negative
    • Anti - Ro: POSITIVE
    • Anti - La: POSITIVE
    • Anti - Topo1: Negative
    • Anti - Jo1: Negative
  • Double Stranded DNA Antibodies
    • dsDNA 0.7  2.7 IU/mL (normal range: 0-4.0)
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Case information

rID: 32605
Published: 2nd Jan 2015
Last edited: 8th Feb 2020
Inclusion in quiz mode: Included

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